Nobody can stop Sanjay's excitement and curiosity about the world -- not even himself! He can be clumsy and isn't always equipped for the situation at hand, but he doesn't know the meaning of the words 'uncool' or 'impossible.' This 12-year-old is a definite charmer, which is handy when your best friend is a snake.
Ever since their chance meeting in a pet store, talking snake Craig and Sanjay have been the best of friends. Craig is convinced he's the coolest guy (err, snake) around, and he tends to exaggerate when he gets excited. He's also a master of disguise and can turn into pretty much anything, including a human! But shhh!! Only Sanjay and his closest friends know Craig's secret.
Sanjay’s dad owns The Close-Out Blow-Out Depot, a wholesale clearance store that sells everything from bargain appliances to bizarre gadgets that he makes himself. Although no one ever buys Vijay’s inventions, he never gets down. Sanjay and Vijay have a great father-son bond. They share the same interests, they have similar personalities, and they’re both big dreamers.
Sanjay’s mother is the ultimate cool mom. She’s an ER nurse who shares Sanjay’s sick sense of humor. At the end of each day, Darlene loves regaling Sanjay with all the disgusting details of what she saw at the hospital. Whether Sanjay wants to see a butt transplant, a giant vat of pus, or get a sonogram of a fart, he turns to Darlene and she never lets him down.
Hector is the friend Sanjay and Craig are always happy to see... at least until he gets annoying. He's a fun-loving goofball and a bit dopey, but extremely brawny and loyal. He believes his eyepatch makes his other senses "superhero" sharp, and always has a quirky new nickname for the group, like "CraigForce 4."
Belle is a sweet, smart, cool older girl and Sanjay’s unrequited crush. Her dad, Penny Pepper, owns the Frycade, the boys’ favorite hot wing and videogame hangout, where she works as a waitress. Unlike most girls, Belle is not afraid of snakes and freely pets Craig, fueling Sanjay and Craig’s never-ending argument over whom she likes more.
Meet Megan Sparkles (a.k.a. Little Miss Lactose Intolerant, Little Miss Adopt-A-Highway, Little Miss Mixed Martial Arts, etc). She's the smart, enthusiastic, and adorable pageant winner who can get carried away at times, but loves helping (and annoying) Sanjay and Craig. Maybe her pageant skills can even help her win Sanjay's heart!
Remington Tufflips may be a washed up action movie star from the '80s but he's the number one awesome-est guy EVER, according to Sanjay and Craig. Tufflips plays it cool all the time and is the ultimate inspiration for these two best friends, even if he can never remember their names.
Leslie Noodman is Sanjay and Craig’s annoying, busybody next-door neighbor. Noodman has a pathological fear of snakes, making Craig his worst nightmare and mortal enemy. A lifelong bachelor, Noodman is unnaturally devoted to his cat, Lady Butterscotch, and is bizarrely obsessed with his favorite food, blueberries. His proximity to Sanjay and Craig’s house often makes him the inadvertent victim of the dudes’ backyard shenanigans, and he’ll take any chance he can get to go after Craig with his trusty snake-smashing shovel.
Grubby siblings Sandy, Scabs, and Baby Richard (Nolan North) are Sanjay’s neighbors and punk rock gods. Outside of Remington Tufflips, they’re the coolest people in Sanjay’s world. Sandy’s the lead singer of their band, the Tuff Skulls. She rides a motorcycle with a sidecar for monosyllabic fraternal twin Scabs, which has an additional sidecar for Baby Richard. Although Sandy and Scabs look like bullies, they’re mostly indifferent to Sanjay and Craig’s adoration and would never intentionally harm them. That's not so with Baby Richard. This diaper-wearing dirtbag is an unpredictable anarchist whose warped brain has earned him the nickname, The Doom Baby.
Tyson is a rude and sarcastic young man. So far he only appeared in Maximum Dennis, and he speaks in a English accent a little bit. He carries a scooter in his pants. He has beaten Sanjay in Tufflips and The Eat Off with the Valcanic Wings, so Sanjay and Craig disguised themselves as Maximum Dennis to beat him in a rematch of Tufflips and the Eat Off. (this time with Sudden Death Wings) Craig jeered at Tyson as he left.
Chicken Chuck is a character in Sanjay and Craig. He first appeared in the episode Maximum Dennis. He was #1 on the wall of wings, but Tyson beat him. (M.D. then defeated Tyson.) Next, he appeared in the episode Heightmare he was riding Floaty Boatys.